Premium
Pazopanib‐induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma
Author(s) -
Horie Shigemitsu,
Nishida Hayato,
Sakurai Toshihiko,
Ichiyanagi Osamu,
Kato Tomoyuki,
Yagi Makoto,
Kabasawa Takanobu,
Asai Teigo,
Tsuchiya Norihiko
Publication year - 2018
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13567
Subject(s) - pazopanib , medicine , discontinuation , liposarcoma , edema , pathology , gastroenterology , sunitinib , sarcoma , renal cell carcinoma
Pazopanib was administered to a 44‐year‐old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.