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Effects of tadalafil on storage and voiding function in patients with male lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A urodynamic‐based study
Author(s) -
Matsukawa Yoshihisa,
Majima Tsuyoshi,
Matsuo Kazuna,
Funahashi Yasuhito,
Kato Masashi,
Yamamoto Tokunori,
Gotoh Momokazu
Publication year - 2018
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13489
Subject(s) - medicine , lower urinary tract symptoms , urology , international prostate symptom score , overactive bladder , hyperplasia , cystometry , bladder outlet obstruction , tadalafil , prostate , urinary system , urinary bladder , erectile dysfunction , pathology , alternative medicine , cancer
Objective To investigate the effects of tadalafil on storage and voiding function in treatment‐naïve patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia, based on a urodynamic study. Methods This was an open‐labeled, single‐center, prospective study. A total of 80 untreated outpatients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia received tadalafil 5 mg/day for 12 weeks. Subjective symptoms and objective findings on voiding and storage function obtained through urodynamic studies, including cystometry and pressure flow study, were evaluated before and after treatment. Results A total of 71 patients with a mean age of 70.2 years and a mean prostate volume of 45.6 mL were included in the analysis. In the International Prostate Symptom Score and Overactive Bladder Symptom Score, mean total scores significantly improved from 18.2 to 13.4 ( P < 0.001) and 6.5 to 4.7 ( P < 0.001), respectively, after treatment. Mean maximum bladder capacity significantly increased by approximately 35 mL ( P < 0.001). Detrusor overactivity disappeared in 15 (39.5%) of 38 patients with detrusor overactivity at baseline ( P < 0.001). Mean maximum flow rate on pressure flow study significantly increased from 7.1 to 9.1 mL/s ( P < 0.001) and mean bladder outlet obstruction index significantly decreased from 61.3 to 47.1 ( P < 0.001). Conclusions Treatment with tadalafil 5 mg once daily effectively relieves lower urinary tract symptoms based on objective improvement of storage and voiding function, such as detrusor overactivity and bladder outlet obstruction, in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.