z-logo
Premium
Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution
Author(s) -
Wang Xianding,
Tu Xiang,
Tan Ping,
Zhan Wenli,
Nie Pan,
Wei Bing,
Li Xiaohong,
Chen Libo,
Lu Yiping,
Han Ping
Publication year - 2017
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13345
Subject(s) - medicine , genitourinary system , sarcoma , univariate analysis , liposarcoma , malignancy , surgery , radiation therapy , incidence (geometry) , multivariate analysis , metastasis , retrospective cohort study , surgical margin , chemotherapy , oncology , resection , cancer , pathology , physics , optics
Objectives To report our institutional experience in the management of adult genitourinary sarcoma. Methods This was a retrospective analysis of data on adult genitourinary sarcoma treated at the West China Hospital, Sichuan University, Chengdu, Sichuan, China from 1985 to 2010. Clinicopathological parameters were analyzed to determine their impact on overall, recurrence‐free and metastasis‐free survivals. Results A total of 46 women and 142 men were included, with a median age of 42 years. Of these, 152 cases were high‐grade. The most common site was the paratesticular region. Surgical resection was carried out in 155 patients (82.4%), with negative margin in 106. After a minimum follow up of 5 years, 20 patients (11.6%) survived disease‐free, 14 (8.1%) were alive with disease and 138 (80.2%) died of disease. Survival rates at 1, 3 and 5 years were 91.3%, 64.0% and 47.7%. In univariate analyses, liposarcoma, high grade, metastasis at diagnosis, a lack of surgical resection and positive margin were predictive of unfavorable survival. In multivariate analyses, high grade, a lack of surgical resection and chemotherapy were independent predictors of poor survival. Conclusions Adult genitourinary sarcoma is an aggressive malignancy, usually presenting at advanced stage, with a high incidence of recurrence and metastasis. Complete resection and selective combination of chemotherapy and radiotherapy might constitute the optimal treatment for this disease.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here