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Androgen receptor splice variant 7 in castration‐resistant prostate cancer: Clinical considerations
Author(s) -
Bryce Alan H,
Antonarakis Emmanuel S
Publication year - 2016
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13134
Subject(s) - enzalutamide , prostate cancer , androgen receptor , splice , medicine , androgen , cancer research , androgen deprivation therapy , oncology , cancer , biology , hormone , genetics , gene
Constitutively‐active ligand‐independent splice variants of the androgen receptor are an adaptive response by prostate cancer cells to escape androgen deprivation therapy and novel androgen receptor ‐directed treatments. Androgen receptor splice variant 7 is the most common splice variant detected in clinical biospecimens, and emerging data now suggest that the presence of tumoral androgen receptor splice variant 7 might be indicative of primary and acquired resistance to next‐generation androgen pathway inhibitors, such as abiraterone and enzalutamide. At the same time, taxane chemotherapy might retain its efficacy regardless of androgen receptor splice variant 7 status, thus suggesting the potential for a predictive biomarker guiding treatment selection in men with metastatic castration‐resistant prostate cancer. Herein, we review the preclinical data elucidating the structure and function of androgen receptor splice variant 7 , we describe the existing clinical data using this biomarker in metastatic castration‐resistant prostate cancer , and we highlight potential therapeutic strategies to target androgen receptor splice variant 7 ‐expressing prostate cancer.