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Optimum anesthesia for reliable urethral pressure profilometry in female dogs and goats
Author(s) -
Dybowski Bartosz,
Burdzińska Anna,
Siewruk Katarzyna,
Dąbrowski Michał,
Pączek Leszek,
Radziszewski Piotr
Publication year - 2016
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13114
Subject(s) - propofol , medicine , isoflurane , sedation , anesthesia , midazolam , coefficient of variation , premedication , reproducibility , statistics , mathematics
Objectives To investigate the effects of propofol and isoflurane on urethral pressure profilometry of female dogs and goats, and to identify the method of anesthesia that least influences urethral pressure profilometry and to assess its reproducibility. Methods The effects of premedication with midazolam, propofol sedation and isoflurane anesthesia were assessed in five female dogs. The effects of propofol and isoflurane were compared in seven goats, whereas in another group of 19 goats, the state of deep propofol sedation was compared with the state of recovery from propofol sedation. The coefficient of reproducibility and within‐subject coefficient of variation were calculated to evaluate test–retest reproducibility. Results In conscious female dogs, maximal urethral closure pressure and functional area were significantly higher than under propofol or isoflurane ( P = 0.04), but not different from the recovery state. In six of seven goats, maximal urethral closure pressure and functional area were higher when measured under propofol sedation than under isoflurane (median maximal urethral closure pressure, 69 vs 47 cmH 2 O; P = 0.03). Maximal urethral closure pressure was lower under propofol than during recovery from propofol in 17 of 19 goats (median maximal urethral closure pressure, 54 vs 66 cmH 2 O; P < 0.001). The test–retest coefficient of reproducibility for goats was 28 cmH 2 O, and the within‐subject coefficient of variation was 16%. Conclusions In dogs, urethral pressure profilometry should be measured in conscious animals whenever possible. In goats, urethral pressure profilometry is least affected during recovery from propofol sedation, and it shows acceptable reproducibility under this condition.