Premium
Clinical application of neutrophil CD64 quantification for differential diagnosis of acute scrotum
Author(s) -
Hayashi Hirofumi,
Mochizuki Taku,
Sanjo Hiroyuki,
Komiya Akiko,
Matsui Toshihiro,
Tohma Shigeto,
Hirai Kotaro
Publication year - 2016
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.13036
Subject(s) - medicine , acute scrotum , testicular torsion , cd64 , differential diagnosis , scrotum , orchitis , pathology , immunology , surgery , antigen
The management of acute scrotum can be challenging, especially in infants or patients with a neurological or neurodevelopmental disorder in whom presentation, diagnosis and definitive management tends to be delayed. This leads to poor outcomes, such as loss of the affected testis. Here we present two cases of testicular torsion in patients with neurodevelopmental disorders, and a further two cases of epidydimo‐orchitis in whom measurement of CD64 expression on neutrophils was helpful for differential diagnosis. These data suggest that the levels of expression of CD64 by neutrophils, known as a marker of infection, could also be useful for differentiating between testicular torsion and infection in acute scrotum.