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Two‐year analysis for predicting renal function and contralateral hypertrophy after robot‐assisted partial nephrectomy: A three‐dimensional segmentation technology study
Author(s) -
Kim Dae Keun,
Jang Yujin,
Lee Jaeseon,
Hong Helen,
Kim Ki Hong,
Shin Tae Young,
Jung Dae Chul,
Choi Young Deuk,
Rha Koon Ho
Publication year - 2015
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12913
Subject(s) - medicine , nephrectomy , renal function , urology , segmentation , muscle hypertrophy , artificial intelligence , kidney , computer science
Objectives To analyze long‐term changes in both kidneys, and to predict renal function and contralateral hypertrophy after robot‐assisted partial nephrectomy. Methods A total of 62 patients underwent robot‐assisted partial nephrectomy, and renal parenchymal volume was calculated using three‐dimensional semi‐automatic segmentation technology. Patients were evaluated within 1 month preoperatively, and postoperatively at 6 months, 1 year and continued up to 2‐year follow up. Linear regression models were used to identify the factors predicting variables that correlated with estimated glomerular filtration rate changes and contralateral hypertrophy 2 years after robot‐assisted partial nephrectomy. Results The median global estimated glomerular filtration rate changes were −10.4%, −11.9%, and −2.4% at 6 months, 1 and 2 years post‐robot‐assisted partial nephrectomy, respectively. The ipsilateral kidney median parenchymal volume changes were −24%, −24.4%, and −21% at 6 months, 1 and 2 years post‐robot‐assisted partial nephrectomy, respectively. The contralateral renal volume changes were 2.3%, 9.6% and 12.9%, respectively. On multivariable linear analysis, preoperative estimated glomerular filtration rate was the best predictive factor for global estimated glomerular filtration rate change on 2 years post‐robot‐assisted partial nephrectomy ( B −0.452; 95% confidence interval −0.84 to −0.14; P = 0.021), whereas the parenchymal volume loss rate ( B −0.43; 95% confidence interval −0.89 to −0.15; P = 0.017) and tumor size ( B 5.154; 95% confidence interval −0.11 to 9.98; P = 0.041) were the significant predictive factors for the degree of contralateral renal hypertrophy on 2 years post‐robot‐assisted partial nephrectomy. Conclusions Preoperative estimated glomerular filtration rate significantly affects post‐robot‐assisted partial nephrectomy renal function. Renal mass size and renal parenchyma volume loss correlates with compensatory hypertrophy of the contralateral kidney. Contralateral hypertrophy of the renal parenchyma compensates for the functional loss of the ipsilateral kidney.