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Hyperbaric oxygen therapy for refractory radiation‐induced hemorrhagic cystitis
Author(s) -
Ribeiro de Oliveira Tiago M,
Carmelo Romão António J,
Gamito Guerreiro Francisco M,
Matos Lopes Tomé M
Publication year - 2015
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12857
Subject(s) - medicine , hemorrhagic cystitis , hyperbaric oxygen , refractory (planetary science) , radiation therapy , surgery , adverse effect , chemotherapy , cyclophosphamide , physics , astrobiology
Objectives To analyze the efficacy of hyperbaric oxygen for the treatment of radiation‐induced hemorrhagic cystitis and to identify factors associated with successful treatment. Methods Clinical records from 176 patients with refractory radiation‐induced hemorrhagic cystitis treated at the Portuguese Navy Center for Underwater and Hyperbaric Medicine, during a 15‐year period, were retrospectively analyzed. Evolution of macroscopic hematuria was used to analyze treatment efficacy and correlated with other external variables. Results From a total of 176 treated patients, 23.9% evidenced other radiation‐induced soft tissue lesions. After an average on 37 sessions, 89.8% of patients showed resolution of hematuria, with only 1.7% of adverse events. In our sample, hematuria resolution after treatment with hyperbaric oxygen was statistically associated to the need for transfusion therapy ( P = 0.026) and the number of sessions of hyperbaric oxygen ( P = 0.042). No relationship was found with the remaining variables. Conclusions Refractory radiation‐induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. Treatment effectiveness seems to be correlated with the need for transfusion therapy and the number of sessions performed.