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Prognostic factors in patients with penile carcinoma and inguinal lymph node metastasis
Author(s) -
Costa Walter Henriques,
Rosa de Oliveira Renato Almeida,
Santana Thiago Borges,
Benigno Bruno Santos,
Cunha Isabela Werneck,
Cássio Zequi Stênio,
Guimaraes Gustavo Cardoso,
Lopes Ademar
Publication year - 2015
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12759
Subject(s) - medicine , lymphovascular invasion , penile carcinoma , lymph node , lymph , penile cancer , univariate analysis , oncology , carcinoma , multivariate analysis , risk factor , lymph node metastasis , metastasis , pathology , cancer
Objectives To identify prognostic factors in patients with penile carcinoma and confirmed lymph node metastasis. Methods Patients were selected from a historical series of patients with penile carcinoma. An experienced pathologist reviewed all cases. Information regarding the total number of lymph nodes excised, the number of positive lymph nodes and the presence of extranodal extension were used. Lymph node ratio was categorized as <0.15 and >0.15. Results The 5‐year recurrence‐free survival and disease‐specific survival rates were 55.3% and 64.1%, respectively. Lymphovascular invasion, lymph node ratio and pN status influenced survival rates in univariate analysis. Lymphovascular invasion and lymph node ratio remained as independent predictors of disease‐specific survival and recurrence‐free survival in the multivariate analysis. A risk stratification of death and tumor recurrence was observed when patients were grouped into three categories: absence of risk factors; the presence of one risk factor; and the presence of two or more risk factors. Conclusions The presence of one or more of the following parameters is correlated with a significantly higher risk of death and tumor recurrence in patients with penile carcinoma and inguinal lymph node metastasis: extranodal extension, lymph node ratio >0.15 and lymphovascular invasion.