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Overweight and high‐sensitivity C ‐reactive protein are weakly associated with kidney stone formation in J apanese men
Author(s) -
Oda Eiji
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12499
Subject(s) - medicine , waist , body mass index , overweight , kidney stones , c reactive protein , circumference , obesity , population , kidney , inflammation , environmental health , geometry , mathematics
Objectives To investigate longitudinal relationships between obesity/inflammation and kidney stone formation in a population where obesity is not prevalent. Methods Using C ox regression models, associations between kidney stone formation and body mass index, waist circumference, high‐sensitivity C ‐reactive protein and other possible risk factors were retrospectively examined in a health screening J apanese population including 1726 men and 992 women. Results During 4 years of follow up (mean 3.2 years), kidney stones were formed in 238 men (34.5 per 1000 person‐years) and 82 women (20.7 per 1000 person‐years). In men, when the possible risk factors were separately examined as continuous parameters, body mass index ( P = 0.030) and waist circumference ( P = 0.025) were significantly, and log C ‐reactive protein ( P = 0.092) were marginally, associated with kidney stone formation. However, none of these parameters was independently associated with kidney stone formation after fully adjusted. In women, none of the aforementioned three parameters was associated with kidney stone formation. As a categorical parameter, the higher two quintiles of C ‐reactive protein were significantly associated with kidney stone formation compared with the lower two quintiles in men ( P = 0.026). Conclusions Overweight and C ‐reactive protein are weakly associated with kidney stone formation in J apanese men. Inflammation might be an underlying mechanism of the association between obesity and kidney stone formation.