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Impact of symptom improvement on patients' bother and quality of life in female patients with overactive bladder treated by solifenacin (SET‐Q)
Author(s) -
Gotoh Momokazu,
Kobayashi Toshimitsu,
Sogabe Keizo
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12355
Subject(s) - overactive bladder , solifenacin , medicine , quality of life (healthcare) , urology , urinary urgency , urinary incontinence , nursing , alternative medicine , pathology
Objectives To analyze the relationship between symptom improvement and health‐related quality of life in female overactive bladder patients treated with solifenacin. Methods We carried out a prospective, multicenter, open‐label study. Eligible patients were treatment‐naive female patients with overactive bladder, with an urgency episode at least once a week. Symptoms were quantitatively assessed by the O veractive B ladder S ymptom S core, and quality of life by the O veractive B ladder questionnaire. Changes of symptom severity, bother, and quality of life were assessed at baseline and 12 weeks after treatment with solifenacin 5, 7.5 or 10 mg once daily. Results Data from 523 patients (mean age 66 years) were analyzed. Solifenacin significantly improved the total O veractive B ladder S ymptom S core and also all subscores for the four symptoms (daytime frequency, urgency, night‐time frequency and urgency incontinence). Solifenacin also significantly improved the four quality of life subscales, total quality of life and symptom bother scores of the O veractive B ladder questionnaire. The severity of night‐time frequency at baseline positively affected the improvement in the quality of life subscale of S leep, and the severity of daytime frequency at baseline positively affected the improvement of coping and social interaction. Improvement of severity in various symptoms positively affected the improvement of bother and the quality of life subscales. Conclusions Solifenacin provides an overall improvement of bother and quality of life in female overactive bladder patients. Symptom severity before treatment and improvement of symptom severity seem to variably affect this improvement.