Premium
Urine alkalization improves the problems of pain and sleep in hypersensitive bladder syndrome
Author(s) -
Ueda Tomohiro,
Yoshida Toru,
Tanoue Hideki,
Ito Masaaki,
Tamaki Masahiro,
Ito Yasuhiko,
Yoshimura Naoki
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12324
Subject(s) - medicine , urine , urination , urinary system , urology , gastroenterology , anesthesia
Objective To investigate the efficacy of urine alkalization therapy using citrates in patients with hypersensitive bladder syndrome. Methods A total of 76 patients with urinary frequency were assessed for their symptoms using a 2‐day voiding diary as well as the urine pH at each voiding during the screening period. Their symptoms were also assessed by pain score, K ing's health questionnaire, and O ' L eary– S ant symptom and problem index scores. Finally, 50 patients were evaluated for changes in symptoms after oral treatment with citrates for 2–4 weeks after the screening period. Results After the treatment, significant increases in the urine pH (from 5.8 ± 0.4 to 6.3 ± 0.4; increment of 0.5 ± 0.4; P < 0.01), and significant decreases in the number of micturitions per day (from 14.5 ± 6.5 to 13.5 ± 5.9; P = 0.02) and the number of episodes of pain/discomfort per day (from 7.8 ± 6.8 to 6.1 ± 7.1; P = 0.02) were observed. In the K ing's health questionnaire, the sleep/energy domain score was significantly improved (from 60.0 ± 25.0 to 50.3 ± 29.6; P < 0.01). In a subgroup analysis based on urine pH (urine pH <6.2 and ≥6.2), significant improvements in the voiding symptoms, the sleep/energy domain score and the O ' L eary– S ant problem index were observed in the group with urine pH of ≥6.2. There were statistically significant differences between the subgroups in the volume per voiding, maximum volume per voiding and the problem index. In addition, the subgroup, in which patients had pain in the screening period, showed statistically significant improvements in the number of micturitions per day, episodes of pain/discomfort per day, the sleep/energy domain score and the problem index. Conclusions Urine alkalization therapy is likely to be effective in the treatment for hypersensitive bladder syndrome.