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Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis
Author(s) -
Yoshimura Naoki,
Oguchi Tomohiko,
Yokoyama Hitoshi,
Funahashi Yasuhito,
Yoshikawa Satoru,
Sugino Yoshio,
Kawamorita Naoki,
Kashyap Mahendra P,
Chancellor Michael B,
Tyagi Pradeep,
Ogawa Teruyuki
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12308
Subject(s) - interstitial cystitis , medicine , bladder pain syndrome , pathophysiology , etiology , urinary system , urology , urinary bladder , afferent , lower urinary tract symptoms , prostate , cancer
Abstract Bladder pain syndrome/interstitial cystitis is a disease with lower urinary tract symptoms, such as bladder pain and urinary frequency, which results in seriously impaired quality of life of patients. The extreme pain and urinary frequency are often difficult to treat. Although the etiology of bladder pain syndrome/interstitial cystitis is still not known, there is increasing evidence showing that afferent hyperexcitability as a result of neurogenic bladder inflammation and urothelial dysfunction is important to the pathophysiological basis of symptom development. Further investigation of the pathophysiology will lead to the effective treatment of patients with bladder pain syndrome/interstitial cystitis.