Premium
Effect of DA ‐8031, a novel oral compound for premature ejaculation, on male rat sexual behavior
Author(s) -
Kang Kyung Koo,
Sung Ji Hyun,
Kim Soon Hoe,
Lee Sukhyang
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12256
Subject(s) - premature ejaculation , ejaculation , medicine , oral administration , pharmacology , pharmacokinetics , sexual behavior , psychology , clinical psychology , psychoanalysis
Objectives DA ‐8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA ‐8031 on male sexual behavior in a rat model. Methods Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA ‐8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA ‐8031 at a dose level of 30 mg/kg. Results DA ‐8031 treatment produced a dose‐dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle ( P < 0.05). In addition, DA ‐8031 treatment reduced the mean number of ejaculations in a dose‐dependent manner. No changes in post‐ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA ‐8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half‐life of 1.79 ± 0.32 h. Conclusions Treatment with DA ‐8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post‐ejaculatory interval in rats. Furthermore, DA ‐8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA ‐8031 as an “on‐demand” agent for premature ejaculation.