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Influence of body mass index on oncological outcomes in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy
Author(s) -
Liu JianYe,
Li YongHong,
Liu ZhouWei,
Zhang ZhiLing,
Ye YunLin,
Yao Kai,
Jiang LiJuan,
Han Hui,
Qin ZiKe,
Zhou FangJian
Publication year - 2014
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12208
Subject(s) - medicine , body mass index , underweight , proportional hazards model , urology , cancer , univariate analysis , oncology , overweight , multivariate analysis
Objective To investigate the association between body mass index and oncological outcomes in C hinese patients who had undergone radical nephroureterectomy for upper urinary tract urothelial carcinoma. Methods Between A ugust 1998 and O ctober 2009, 236 consecutive C hinese patients underwent radical nephroureterectomy for upper urinary tract urothelial carcinoma at Sun Yat‐sen University Cancer Center (Guangzhou, China). Body mass index data were available for 230 (97.5%) of these patients. All 230 patients were classified into three groups according to the body mass index criteria for A sians, issued by the A sia C ohort C onsortium: underweight, body mass index <18.5 kg/m 2 ( n = 21, 9.1%); normal weight, body mass index ≥18.5 and <25 kg/m 2 ( n = 151, 65.7%); and obesity, body mass index ≥25 kg/m 2 , ( n = 58, 25.2%). Spearman's rank correlation, K aplan– M eier plots and C ox proportional hazards regression model were used to analyze the data. Results Being underweight was significantly associated with lymph node metastasis ( P = 0.017) and Eastern Cooperative Oncology Group performance status ( P = 0.003). Univariate analysis showed recurrence‐free survival and cancer‐specific survival were significantly worse in underweight patients than in patients with normal weight or obese patients. After adjustments for other clinicopathological variables, multivariate analysis confirmed that recurrence‐free survival and cancer‐specific survival were significantly worse in underweight patients than in patients with normal weight or obese patients (recurrence‐free survival P = 0.014, cancer‐specific survival P = 0.015). Conclusions Preoperative underweight is an independent predictor of unfavorable recurrence‐free survival and cancer‐specific survival in C hinese patients with upper urinary tract urothelial carcinoma treated by radical nephroureterectomy, whereas obesity is associated with superior recurrence‐free survival and cancer‐specific survival. Further studies, including a multi‐institutional, prospective, A sian cohort study, are required to confirm these findings.