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Spindle cell rhabdomyosarcoma of the prostate
Author(s) -
Latz Stefan,
Ellinger Jörg,
Goltz Diane,
Marx Christian,
Leuschner Ivo,
Müller Stefan C,
Fechner Guido
Publication year - 2013
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12082
Subject(s) - medicine , rhabdomyosarcoma , ifosfamide , embryonal rhabdomyosarcoma , vincristine , chemotherapy , radiation therapy , prostate , biopsy , pathology , oncology , urology , radiology , sarcoma , surgery , cancer , cyclophosphamide , cisplatin
The spindle cell rhabdomyosarcoma is a rare variant of the embryonal rhabdomyosarcoma, mostly occurring in childhood. Only a few cases are described in adults. To date, no case of the spindle cell subtype of the prostatic embryonal rhabdomyosarcoma has been published. We report on a 23‐year‐old man, initially presenting with obstructive micturition problems, perineal pain and night sweat. After diagnosis by transrectal biopsy of the prostate, radiochemotherapy within the CWS 2002 P study was applied: nine cycles of vincristine, doxorubicin, actinomycin D, ifosfamide, and fractionated radiotherapy of the tumor and suspect lymph nodes (final dose 50.4 G y). The tumor initially shrank, but an early local recurrence arose. Second‐line chemotherapy was applied, followed by a salvage radical cytoprostatectomy. The patient died of disseminated disease 14 months after diagnosis.