Premium
Presurgical downstaging of vena caval tumor thrombus in advanced clear cell renal cell carcinoma using temsirolimus
Author(s) -
Sano Futoshi,
Makiyama Kazuhide,
Tatenuma Tomoyuki,
Sakata Ryoko,
Yamanaka Hiroyuki,
Fusayasu Syusei,
Nakayama Takashi,
Nakaigawa Noboru,
Yao Masahiro,
Kubota Yoshinobu
Publication year - 2013
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/iju.12012
Subject(s) - temsirolimus , medicine , renal cell carcinoma , nephrectomy , inferior vena cava , thrombus , pathological , renal vein , radiology , urology , surgery , kidney , discovery and development of mtor inhibitors , apoptosis , biochemistry , chemistry , protein kinase b
A 63‐year‐old man presenting with a 7.2‐cm right renal mass, an inferior vena cava tumor thrombus, and pulmonary metastases underwent renal mass biopsy that revealed clear cell renal cell carcinoma. Temsirolimus (25 mg weekly) was given because of the extent of the disease and poor performance status, which resulted in a marked reduction in the tumor thrombus (from level III to level I ) after 20 weeks of treatment. Subsequently, radical nephrectomy and tumor thrombectomy were carried out. Final pathological analysis confirmed the diagnosis of high‐grade clear cell carcinoma ( pT4N0M1 ). One year after initiation of temsirolimus therapy, the patient remained alive despite the presence of disease.