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Fatty liver disease, glucose tolerance and insulin resistance in obese adolescents
Author(s) -
Slyper A. H.,
Rosenberg H.,
Kabra A.,
Huang W.M.,
Blech B.,
Matsumura M. M.
Publication year - 2015
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.279
Subject(s) - medicine , insulin resistance , endocrinology , postprandial , type 2 diabetes , insulin , body mass index , glucose homeostasis , fatty liver , diabetes mellitus , intra abdominal fat , visceral fat , disease
Summary Background/objectives Adult studies suggest that intra‐hepatic fat predicts 2‐h blood glucose levels and type 2 diabetes, and may have a role in the development of insulin resistance. Our study objective was to explore relationships between intra‐hepatic fat and (i) blood glucose levels and (ii) insulin resistance determined by homeostasis model assessment ( HOMA ) in a group of obese adolescents. Methods Subjects were 61 obese non‐diabetic male and female volunteers aged 12–18 years inclusive with a body mass index >95th percentile for age and 2‐h blood glucose <200 mg dL −1 . Each subject underwent 2‐h glucose tolerance testing and measurement of haemoglobin A 1c, ultrasensitive C ‐reactive protein and fasting insulin. Visceral, subcutaneous abdominal and intra‐hepatic fat were determined by magnetic resonance imaging. Intra‐hepatic fat was measured by gradient echo chemical shift imaging. Results Alanine aminotransferase levels and hepatic phase difference were not significant correlates of fasting or 2‐h glucose. In a multiple regression model including hepatic phase difference and visceral fat volume, visceral fat volume was the sole predictor of HOMA . Conclusions This study provides no support to the notion that intra‐hepatic fat has a role in the regulation of fasting blood glucose, 2‐h postprandial blood glucose or systemic insulin resistance.