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Depressive symptoms are associated with fasting insulin resistance in obese youth
Author(s) -
Han T. S.,
Li Z.,
Tu W.,
Huber J. N.,
Carroll A. E.,
Lagges A. M.,
Gupta S.
Publication year - 2014
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.237
Subject(s) - insulin resistance , medicine , depression (economics) , obesity , body mass index , insulin , depressive symptoms , homeostatic model assessment , endocrinology , diabetes mellitus , economics , macroeconomics
Summary Background In adults, depressive symptoms are positively associated with insulin resistance. Objective To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. Methods This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms ( C hildren's D epression I nventory, CDI ) and fasting insulin and homeostatic model assessment‐insulin resistance ( HOMA‐IR ) in obese youth ( n = 207, age 10–18 years). Individuals with lower vs. higher CDI T ‐scores (<65 vs. ≥65) were compared; this cut‐point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T ‐scores and insulin resistance. Results Fasting insulin and HOMA‐IR values were 40% higher in patients with higher CDI T ‐scores ( P = 0.04). After accounting for gender, race, age and body mass index, CDI T ‐score remained associated with HOMA‐IR , although the strength of the association was small (b = 0.007, P = 0.049). Conclusions Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.