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Dietary inflammation and cardiometabolic health in adolescents
Author(s) -
Sethna Christine B.,
Alanko Daniel,
Wirth Michael D.,
Shivappa Nitin,
Hebert James R.,
Khan Samira,
Sen Sarbattama
Publication year - 2021
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12706
Subject(s) - medicine , albuminuria , quartile , dyslipidemia , overweight , obesity , blood pressure , national health and nutrition examination survey , body mass index , cross sectional study , endocrinology , population , confidence interval , environmental health , pathology
Summary Background The Children's Dietary Inflammatory Index (C‐DII) has been validated to characterize the inflammatory potential of an individual child's diet. Objective To determine the association between C‐DII and markers of cardiometabolic risk (adiposity, blood pressure [BP], lipids, albuminuria, glomerular hyperfiltration) in adolescents. Methods Participants aged 12‐18 enrolled in NHANES from 2005 to 2014 who completed a 24‐hour dietary recall were included in this cross‐sectional study. Regression models adjusted for age, sex, race and height examined associations of C‐DII quartiles stratified by weight status. Results Among adolescents (mean age 15 years), the average C‐DII score was 0.86 (SE 0.04). When comparing C‐DII quartile 4 (most pro‐inflammatory) to quartile 1 (most anti‐inflammatory), there was a positive association with albuminuria (OR 1.44, 95% CI 1.02, 2.03). After stratifying by weight status, C‐DII quartile was found to be significantly associated with albuminuria (OR 4.27, 95% CI 1.83, 9.92) and dyslipidemia (OR 1.87, 95% CI 1.15, 3.03) in adolescents who were overweight. Among adolescents with obesity, C‐DII quartile was associated with higher SBP ( β = 5.07, 95% CI 2.55‐7.59) and lower DBP ( β = −4.14, 95% CI −6.74, −1.54). Conclusion Consuming a pro‐inflammatory diet in adolescence was associated with alterations in albuminuria, lipid and BP measures.