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Lean mass index is positively associated with white matter volumes in several brain regions in children with overweight/obesity
Author(s) -
GraciaMarco Luis,
EstebanCornejo Irene,
UbagoGuisado Esther,
RodriguezAyllon Maria,
MoraGonzalez Jose,
SolisUrra Patricio,
CadenasSanchez Cristina,
VerdejoRoman Juan,
Catena Andres,
Erickson Kirk I.,
Ortega Francisco B.
Publication year - 2020
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12604
Subject(s) - overweight , body mass index , medicine , white matter , obesity , grey matter , covariate , regression analysis , magnetic resonance imaging , demography , statistics , mathematics , radiology , sociology
Summary Background The relationship of obesity with grey and white matter volumes has been examined in several studies, and the results are decidedly mixed. Objective To investigate the associations of body mass index (BMI), fat mass index (FMI) and lean mass index (LMI) with total and regional grey and white matter volumes. Methods This is a cross‐sectional study involving 100 children (60% boys) with overweight/obesity. T1‐weighted images were acquired using magnetic resonance imaging. Dual energy X‐ray absorptiometry was used to measure body composition. Separate hierarchical regression analyses were performed between predictor variables (BMI, FMI and LMI) and the total brain volumes including sex, years from peak height velocity and parental education as covariates. In addition, FMI was added as a covariate when LMI was the predictor and vice versa. Statistical analyses of imaging data were performed using three whole‐brain voxel‐wise multiple regression models and adjusted by the same covariates. Results LMI was positively associated with white matter in numerous regions and to a lower extent, with grey matter regions. Further, the relationship between LMI, and grey and white matter regions was independent of FMI levels. Conclusions LMI seems to be a positive predictor of regional white matter volumes in children with overweight/obesity.