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Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents
Author(s) -
Lundström Elin,
Ljungberg Joy,
Andersson Jonathan,
Manell Hannes,
Strand Robin,
Forslund Anders,
Bergsten Peter,
Weghuber Daniel,
Mörwald Katharina,
Zsoldos Fanni,
Widhalm Kurt,
Meissnitzer Matthias,
Ahlström Håkan,
Kullberg Joel
Publication year - 2019
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12531
Subject(s) - medicine , adipose tissue , endocrinology , body mass index , obesity , insulin resistance , carbohydrate metabolism , diabetes mellitus , overweight , magnetic resonance imaging , glucose homeostasis , type 2 diabetes , radiology
Summary Background Despite therapeutic potential against obesity and diabetes, the associations of brown adipose tissue (BAT) with glucose metabolism in young humans are relatively unexplored. Objectives To investigate possible associations between magnetic resonance imaging (MRI) estimates of BAT and glucose metabolism, whilst considering sex, age, and adiposity, in adolescents with normal and overweight/obese phenotypes. Methods In 143 subjects (10‐20 years), MRI estimates of BAT were assessed as cervical‐supraclavicular adipose tissue (sBAT) fat fraction (FF) and T 2 * from water‐fat MRI. FF and T 2 * of neighbouring subcutaneous adipose tissue (SAT) were also assessed. Adiposity was estimated with a standardized body mass index, the waist‐to‐height ratio, and abdominal visceral and subcutaneous adipose tissue volumes. Glucose metabolism was represented by the 2h plasma glucose concentration, the Matsuda index, the homeostatic model assessment of insulin resistance, and the oral disposition index; obtained from oral glucose tolerance tests. Results sBAT FF and T 2 * correlated positively with adiposity before and after adjustment for sex and age. sBAT FF, but not T 2 * , correlated with 2h glucose and Matsuda index, also after adjustment for sex, age, and adiposity. The association with 2h glucose persisted after additional adjustment for SAT FF. Conclusions The association between sBAT FF and 2h glucose, observed independently of sex, age, adiposity, and SAT FF, indicates a role for BAT in glucose metabolism, which potentially could influence the risk of developing diabetes. The lacking association with sBAT T 2 * might be due to FF being a superior biomarker for BAT and/or to methodological limitations in the T 2 * quantification.