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Towards a circulating marker of hepato‐visceral fat excess: S100A4 in adolescent girls with polycystic ovary syndrome — Evidence from randomized clinical trials
Author(s) -
Malpique Rita,
SánchezInfantes David,
GarciaBeltran Cristina,
Taxerås Siri D.,
LópezBermejo Abel,
Zegher Francis,
Ibáñez Lourdes
Publication year - 2019
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12500
Subject(s) - polycystic ovary , medicine , endocrinology , adipose tissue , body mass index , hyperandrogenism , visceral fat , insulin resistance , obesity
Summary S100A4 is a marker of subcutaneous adipose tissue dysfunction. Polycystic ovary syndrome (PCOS) is often driven by hepato‐visceral adiposity. PCOS phenotypes are normalized more by reduction of central fat with spironolactone/pioglitazone/metformin (SPIOMET) than by oral contraceptive (OC) treatment. We studied whether circulating S100A4 concentrations are high in adolescents with PCOS and, if so, whether they normalize more with OC or SPIOMET. Assessments included circulating S100A4, endocrine markers, body composition, abdominal fat partitioning in controls (n = 12) and girls with PCOS (n = 51; age 15.8 y; body mass index [BMI] 24.5 kg/m 2 ), and 1‐year changes in girls with PCOS randomized for OC (n = 27) or SPIOMET (n = 24) treatment. Mean S100A4 concentrations were 71% higher ( P < 0.001) in girls with PCOS than in controls and associated with hepato‐visceral adiposity ( r = 0.47; P = 0.001); S100A4 concentrations decreased more ( P < 0.01) with SPIOMET, those decreases associating to hepato‐visceral fat loss ( r = 0.50; P < 0.0001). S100A4 may become a circulating marker of hepato‐visceral fat excess in adolescents with PCOS.