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Newborn adipokines and early childhood growth
Author(s) -
Yeung E. H.,
Sundaram R.,
Xie Y.,
Lawrence D. A.
Publication year - 2018
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12283
Subject(s) - resistin , medicine , adipokine , adiponectin , leptin , childhood obesity , overweight , anthropometry , obesity , odds ratio , endocrinology , pediatrics , insulin resistance
Summary Background While adipokines can regulate satiety and energy metabolism, whether they are associated with childhood growth is unclear. Objective To evaluate whether adipokine levels at birth are associated with growth. Methods A total of 2264 singletons and 1144 twins from Upstate KIDS (born 2008–2010) had adiponectin, leptin, resistin and complement factor D measured in newborn blood spots. Parents reported anthropometry from paediatric visits via questionnaires every 4–6 months. Generalized linear mixed effects models were used to estimate growth trajectories through 3 years of age. Results Among singletons, resistin and leptin were associated with greater weight‐for‐age (0.12 z‐score units (95%CI: 0.04, 0.20) [ p = 0.003] and 0.15 (0.06, 0.24) [ p = 0.001], respectively) and BMI z‐score (0.11; 0.02, 0.20 [ p = 0.02] and 0.18; 0.07, 0.28 [ p = 0.002], respectively). After adjusting for birthweight, resistin and a ratio of resistin‐to‐adiponectin remained associated with weight through 3 years of age and odds of being overweight at 3 years of age in a subgroup of singletons. Among twins, adiponectin was associated with increased weight‐for‐age and length‐for‐age z‐scores even after adjusting for birthweight (0.18; 0.08, 0.28 [ p = 0.0006]; 0.20; 0.07, 0.33 [ p = 0.003], respectively). Conclusions Levels of adipokines were associated with early childhood growth in small magnitudes. Resistin may be relevant for further examination in paediatric obesity.