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Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study
Author(s) -
Li A.,
RobiouduPont S.,
Anand S. S.,
Morrison K. M.,
McDonald S. D.,
Atkinson S. A.,
Teo K. K.,
Meyre D.
Publication year - 2018
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12205
Subject(s) - medicine , single nucleotide polymorphism , obesity , body mass index , birth weight , childhood obesity , longitudinal study , demography , pregnancy , genetics , genotype , overweight , biology , gene , pathology , sociology
Summary Background The genetic influence on child obesity has not been fully elucidated. Objective This study investigated the parental and child contributions of 83 adult body mass index (BMI)‐associated single‐nucleotide polymorphisms (SNPs) to obesity‐related traits in children from birth to 5 years old. Methods A total of 1402 individuals were genotyped for 83 SNPs. An unweighted genetic risk score (GRS) was generated by the sum of BMI‐increasing alleles. Repeated weight and length/height were measured at birth, 1, 2, 3 and 5 years of age, and age‐specific and sex‐specific weight and BMI Z ‐scores were computed. Results The GRS was significantly associated with birthweight Z ‐score ( P = 0.03). It was also associated with weight/BMI Z ‐score gain between birth and 5 years old ( P = 0.02 and 6.77 × 10 −3 , respectively). In longitudinal analyses, the GRS was associated with weight and BMI Z ‐score from birth to 5 years ( P = 5.91 × 10 −3 and 5.08 × 10 −3 , respectively). The maternal effects of rs3736485 in DMXL2 on weight and BMI variation from birth to 5 years were significantly greater compared with the paternal effects by Z test ( P = 1.53 × 10 −6 and 3.75 × 10 −5 , respectively). Conclusions SNPs contributing to adult BMI exert their effect at birth and in early childhood. Parent‐of‐origin effects may occur in a limited subset of obesity predisposing SNPs.