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Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively
Author(s) -
Lipsky LM,
Gee B,
Liu A,
Nansel TR
Publication year - 2017
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12167
Subject(s) - medicine , adiponectin , body mass index , endocrinology , glycated hemoglobin , blood pressure , type 2 diabetes , diabetes mellitus , obesity , insulin resistance
Background The impact of excess weight on cardiovascular disease risk in type 1 diabetes patients is unclear. Objective This study examined associations of BMI and body composition with cardiovascular risk factors in youth followed prospectively for 18 months. Methods The sample includes youth with type 1 diabetes (N = 136, baseline age = 12.3 ± 2.5y, glycated hemoglobin = 8.1 ± 1.1%) participating in an 18‐month behavioral nutrition intervention trial. BMI, body composition (by dual energy x‐ray absorptiometry), total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C); triglycerides (TG), c‐reactive protein (CRP), 8‐iso‐prostaglandin‐F2alpha (8‐iso‐PGF2α), adiponectin and systolic and diastolic blood pressure (SBP and DBP, respectively) were assessed at clinic visits every 6 months. Random effects regression models for repeated measures estimated associations of time‐varying BMI and body composition with time‐varying cardiovascular risk factors, adjusted for treatment assignment and covariates. Results There was no intervention effect on cardiovascular risk factors. Percent body fat was positively associated with TG, LDL‐C, CRP, SBP and DBP, while trunk fat mass and trunk %fat were associated positively with TG, LDL‐C, CRP, SBP and DBP, and inversely with HDL‐C. Higher BMI was associated with greater TG, CRP, SBP and DBP and lower HDL‐C. BMI and body composition indicators were unrelated to 8‐iso‐PGF2α and adiponectin. Conclusions Excess adiposity is associated with increased cardiovascular risk factors in this sample of youth with type 1 diabetes. Non‐significant associations with adiponectin and 8‐iso‐PGF2α suggest potential differences from the general population in the role of adiposity in cardiovascular health.