Premium
α ‐Defensins and bacterial/permeability‐increasing protein as new markers of childhood obesity
Author(s) -
PratsPuig A.,
GispertSaüch M.,
CarrerasBadosa G.,
Osiniri I.,
SorianoRodríguez P.,
PlanellaColomer M.,
Zegher F.,
Ibánez L.,
Bassols J.,
LópezBermejo A.
Publication year - 2017
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12118
Subject(s) - waist , medicine , adiponectin , body mass index , obesity , childhood obesity , abdominal obesity , intima media thickness , endocrinology , blood pressure , insulin resistance , carotid arteries , overweight
Summary Objectives The aim of this paper is to test whether α ‐defensins and bacterial/permeability‐increasing protein were related to obesity and cardiovascular risk factors in prepubertal children. Methods Plasma α ‐defensins and bacterial/permeability‐increasing protein, body mass index (BMI), waist circumference, systolic blood pressure (SBP), carotid intima media thickness (cIMT), HOMA‐IR and HMW‐adiponectin were assessed. Results In a cross‐sectional study ( N = 250), higher α‐defensins concentrations were positively associated with BMI, waist, SBP, cIMT, HOMA‐IR and negative correlated with HMW‐adiponectin (all between r = 0.191 and r = 0.377, p ≤ 0.01 and p ≤ 0.0001). Conversely, plasma bacterial/permeability‐increasing protein concentrations presented inversed associated with the same parameters (all between r = −0.124 and r = −0.329; p ≤ 0.05 and p ≤ 0.0001). In a longitudinal study ( N = 91), α ‐defensins at age 7 were associated with BMI ( β = 0.189, p = 0.002; model R 2 = 0.847) and waist ( β = 0.241, p thinsp;= 0.001; model R 2 = 0.754) at age 10. Conclusions α ‐Defensins and bacterial/permeability‐increasing protein may be the markers of childhood obesity. Increased concentrations of α ‐defensins may predict BMI and abdominal fat deposition in children.