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Does youth adiposity, or change in adiposity from youth to adulthood, predict metabolically healthy obesity in adulthood?
Author(s) -
Smith K. J.,
Bessell E.,
Magnussen C. G.,
Dwyer T.,
Venn A. J.
Publication year - 2016
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12065
Subject(s) - medicine , waist , obesity , body mass index , endocrinology , young adult , metabolic syndrome , demography , sociology
Summary Background Individuals with metabolically healthy obesity ( MHO ) do not have the metabolic complications usually associated with obesity. Objective To examine whether youth adiposity, or change in adiposity from youth to adulthood, predicts MHO 20 years later. Methods A national sample of 2410 Australian participants had height, weight and waist circumference ( WC ) measured in 1985 (7–15 years old) and 2004–2006 (26–36 years old). A fasting blood sample was taken in 2004–2006. MHO was defined as body mass index ( BMI ) ≥30 kg m −2 , normal fasting glucose (<5.6 mmol L −1 ), triglycerides (<1.695 mmol L −1 ), high‐density lipoprotein‐cholesterol (>1.036 mmol L −1 men, > 1.295 mmol L −1 women), blood pressure (<130/85 mmHg) and no medication for these conditions. Relative risks (RR) were calculated using log binomial regression and expressed per unit of youth BMI (or WC ) z‐score or change in BMI (or WC ) z‐score from youth to adulthood, adjusted for sex and youth age. Results In total 323 individuals were obese at follow‐up, 79 (24.5%) were MHO . Adult MHO was not associated with youth BMI ( RR : 1.00, 95% CI : 0.85–1.19) or WC ( RR : 0.93, 95% CI : 0.79–1.11). Individuals were less likely to be MHO if they had larger increases in BMI ( BMI RR : 0.74, 95% CI : 0.57–0.97) or WC ( RR : 0.70, 95% CI : 0.55–0.90) from youth to adulthood. Conclusions Change in adiposity from youth to adulthood predicted adult MHO better than youth adiposity alone.