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Association between abdominal fat distribution, adipocytokines and metabolic alterations in obese low‐birth‐weight children
Author(s) -
Domínguez Hernández C.,
Klünder Klünder M.,
Huang F.,
Flores Armas E. M.,
VelázquezLópez L.,
MedinaBravo P.
Publication year - 2016
Publication title -
pediatric obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.226
H-Index - 69
eISSN - 2047-6310
pISSN - 2047-6302
DOI - 10.1111/ijpo.12060
Subject(s) - medicine , adipokine , abdominal obesity , obesity , abdominal fat , low birth weight , endocrinology , metabolic syndrome , leptin , obstetrics , physiology , pregnancy , biology , genetics
Summary Background In addition to obesity, low birth weight ( LBW ) has been proposed as another independent risk factor associated with cardiovascular disease and type 2 diabetes mellitus. Objective This study aimed to evaluate the influence of birth weight on abdominal fat distribution, adipocytokine levels and associated metabolic alterations in obese children. Methods A cross‐sectional study was conducted in 92 children. Children were divided into three groups according to their body mass index and birth weight. Glucose and insulin (0 and 120 min), lipid profile and adipocytokines were measured. Abdominal fat distribution was assessed by magnetic resonance imaging. Results Obese LBW children had higher fasting glucose ( P = 0.054) and insulin ( P < 0.001), and 120 min glucose ( P < 0.001) and insulin levels ( P < 0.001), such as increased HOMA‐IR (homeostasis model assessment of insulin resistance index) ( P < 0.001). Obesity and LBW were associated with lower concentrations of high molecular weight ( HMW ) adiponectin (−2.38 [ IC 95% −4.27; −0.42, P = 0.018]) and higher subcutaneous adipose tissue ( SAT ) (28.05 [ IC 95% 0.40; 55.7, P = 0.047]) compared with NBW obese children, independent of age or sex. Conclusions LBW in obese children is associated with lower HMW adiponectin, increased insulin resistance and greater SAT .