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Low prevalence of antiannexin A5 antibodies in unprovoked venous thrombosis
Author(s) -
Ho Wai Khoon,
Rigano Joseph
Publication year - 2021
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.13492
Subject(s) - medicine , lupus anticoagulant , thrombosis , pregnancy , venous thrombosis , antiphospholipid syndrome , autoantibody , antibody , immunology , genetics , biology
The antiphospholipid syndrome (APS) is characterized by thrombosis or pregnancy morbidity, and the detection in the blood of at least one of three antiphospholipid antibodies (lupus anticoagulant, or anticardiolipin or anti‐β 2 ‐glycoprotein I antibodies). Diagnosing APS is important so that secondary prophylaxis may be administered to reduce risk of recurrent thrombosis and/or pregnancy morbidity. In addition to APS‐defining antibodies, there may be additional autoantibodies that have a role in thrombosis and/or pregnancy morbidity. Furthermore, some patients have clinical manifestations highly suggestive of APS but are persistently negative for the APS‐defining antibodies (“seronegative APS”) and instead, have other autoantibodies. Antiannexin A5 (aANXA5) autoantibodies have been associated with increased risk of thrombosis and pregnancy morbidity; levels are also reportedly higher in patients with venous thrombosis compared with healthy controls. The prevalence of aANXA5 among patients with unprovoked venous thrombosis is not well‐documented and determination of the frequency of aANXA5 is the objective of this study. Methods We analysed sera from 148 patients with unprovoked venous thrombosis who had undergone routine laboratory testing for the present APS‐defining antibodies. Results aANXA5 IgG and IgM were present in 6% and 1%, respectively. Conclusion Prevalence of these antibodies in unprovoked venous thrombosis is comparable with frequencies reported in healthy individuals and is far lower than the prevalence in women with pregnancy morbidity. This may indicate lack of association with venous thrombosis, however, adequately powered case‐control studies will be required to resolve this and prevalence data from this study will assist in the design of such studies.