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Osteopontin is highly secreted in the cerebrospinal fluid of patient with posterior pituitary involvement in Langerhans cell histiocytosis
Author(s) -
Li Na,
Cui Lei,
Ma Honghao,
Gong Zhihua,
Lian Hongyun,
Wang Chanjuan,
Zhang Qing,
Zhao Xiaoxi,
Chen Xihua,
Tian Yu,
Yang Ying,
Wei Ang,
Zhang Rui,
Li Zhigang,
Wang Tianyou
Publication year - 2020
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.13304
Subject(s) - posterior pituitary , langerhans cell histiocytosis , osteopontin , medicine , cerebrospinal fluid , diabetes insipidus , pathology , magnetic resonance imaging , histiocytosis , gastroenterology , pituitary gland , hormone , disease , radiology
Background Langerhans cell histiocytosis (LCH) is a rare disease caused by clonal proliferation of CD1a + CD207 + cells. Distinguishing pituitary involvement was essential in stratification and treatment of patients with LCH. The diagnosis of pituitary involvement is mainly dependent on hormone abnormalities in the anterior pituitary and magnetic resonance imaging (MRI) scanning in posterior pituitary. Diabetes insipidus (DI) is a serious sequelae and often occurred with pituitary involvement. It is reported that osteopontin (OPN) is highly secreted in the cerebrospinal fluid (CSF) of patients with neurodegenerative diseases in LCH (LCH‐ND). However, patients with posterior pituitary involvement account for a larger portion in our hospital. Whether the OPN level could be an auxiliary diagnostic marker for the posterior pituitary involvement or not is still unknown. Methods In our study, we collected CSF samples of 57 children with LCH. The secreted OPN (sOPN) levels in CSF were measured through enzyme‐linked immunosorbent assay (ELISA). Results After the retrospective analysis of 57 patients with LCH, we found that the sOPN levels in CSF of children with posterior pituitary involvement were significantly higher than that of other groups. After the Pearson Chi‐Square test, Fisher's exact test and ROC analysis, we found that the sOPN levels were significantly correlated with posterior pituitary involvement. The cut‐off value is 214.14 ng/mL. Conclusion The sOPN levels were elevated in CSF of LCH children with posterior pituitary involvement. Analysis of the sOPN level may provide more accurate auxiliary diagnostic techniques for the clinic.