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T‐cell prolymphocytic leukemia: Review of an entity and its differential diagnostic considerations
Author(s) -
Frater John L.
Publication year - 2020
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.13180
Subject(s) - prolymphocytic leukemia , differential diagnosis , lymphocytosis , medicine , leukemia , hematopathology , pathology , immunology , biology , cytogenetics , chronic lymphocytic leukemia , gene , genetics , chromosome
T‐cell prolymphocytic leukemia (T‐PLL) is a rare T‐cell leukemia characterized in many patients by marked peripheral lymphocytosis, prominent splenomegaly, and skin lesions. The differential diagnosis is broad and includes other T‐cell disorders presenting with similar clinical findings. This review addresses (a) the natural history, demographics, and genetic features of T‐PLL; (b) clinical and pathologic differential diagnostic considerations; and (c) recent developments in the T‐PLL literature relevant to laboratory professionals.