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Establishment of new complete blood count reference values for healthy Thai adults
Author(s) -
Wongkrajang P.,
Chinswangwatanakul W.,
Mokkhamakkun C.,
Chuangsuwanich N.,
Wesarachkitti B.,
Thaowto B.,
Laiwejpithaya S.,
Komkhum O.
Publication year - 2018
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12843
Subject(s) - medicine , complete blood count , hematocrit , mean corpuscular volume , reference range , red blood cell distribution width , reference values , blood count , population , hemoglobin , mean corpuscular hemoglobin concentration , physiology , environmental health
Laboratory reference ranges are essential for diagnostic orientation and treatment decision. As complete blood count parameters are influenced by various factors, including gender, geographic origin, and ethnic origin, it is important to establish specific hematologic reference values for specific populations. Methods This study was conducted at the Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Blood samples were taken from healthy adults aged 18‐60 years that attended a health check‐up program at our hospital during February 2015 to July 2015. Hematologic and routine chemistry analysis were performed. Participants were determined to be healthy based on medical history and routine medical examinations. Serum vitamin B12, folate, ferritin, and hemoglobin typing were also analyzed to exclude the possible presence of anemia. Results A statistically significant difference was observed between males and females for Hb level, hematocrit level, red blood cell count, mean corpuscular hemoglobin concentration, percentage neutrophils, monocytes and eosinophils, and absolute neutrophil, lymphocyte, basophil, and platelet counts. Accordingly, gender‐specific reference intervals were established for all complete blood count parameters in healthy Thai adult population. Conclusions The reference value ranges established in this study reflect significant differences between genders. It is possible that these reference ranges may be generalizable to adults living in Thailand. The findings of this study emphasize the importance of establishing specific hematologic reference values for specific populations.