Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma

Abstract Introduction This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma ( BMI ) on laboratory data and to determine the useful laboratory markers for diagnosing BMI . Methods We compared laboratory data between patients with and without BMI . We performed multivariate logistic regression and receiver operating characteristic ( ROC ) analyses to evaluate the diagnostic values of independent predictors. Results In the BMI group, platelets in peripheral blood ( PLT ) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non‐ BMI group ( PLT , P  < .0001; MgK, P  = .0384). The rate of peripheral blood involvement by malignant lymphoma ( PBI ), red blood cell distribution width ( RDW ), D‐dimer ( DD ), soluble interleukin‐2 receptor ( sIL 2R), aspartate aminotransferase ( AST ), and lactate dehydrogenase ( LDH ) was significantly higher in the BMI group than in the non‐ BMI group ( PBI , P  < .0001; RDW , P  = .0190; DD , P  = .0006; sIL 2R, P  < .0001; AST , P  = .0256; LDH , P  = .0002). In multivariate analysis, PBI , PLT , sIL 2R, and MgK levels were independent predictors of BMI. Conclusion PBI , PLT , sIL 2R, and MgK may be the useful laboratory markers for BMI diagnosis.