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Useful laboratory markers for the diagnosis of bone marrow involvement by malignant lymphoma
Author(s) -
Nishimura K.,
Ota R.,
Mikajiri Y.,
Takahashi K.,
Sugishima S.,
Eto T.
Publication year - 2018
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12725
Subject(s) - medicine , lactate dehydrogenase , bone marrow , gastroenterology , logistic regression , red blood cell distribution width , lymphoma , receiver operating characteristic , platelet , peripheral blood , multivariate analysis , body mass index , pathology , biology , biochemistry , enzyme
Abstract Introduction This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma ( BMI ) on laboratory data and to determine the useful laboratory markers for diagnosing BMI . Methods We compared laboratory data between patients with and without BMI . We performed multivariate logistic regression and receiver operating characteristic ( ROC ) analyses to evaluate the diagnostic values of independent predictors. Results In the BMI group, platelets in peripheral blood ( PLT ) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non‐ BMI group ( PLT , P < .0001; MgK, P = .0384). The rate of peripheral blood involvement by malignant lymphoma ( PBI ), red blood cell distribution width ( RDW ), D‐dimer ( DD ), soluble interleukin‐2 receptor ( sIL 2R), aspartate aminotransferase ( AST ), and lactate dehydrogenase ( LDH ) was significantly higher in the BMI group than in the non‐ BMI group ( PBI , P < .0001; RDW , P = .0190; DD , P = .0006; sIL 2R, P < .0001; AST , P = .0256; LDH , P = .0002). In multivariate analysis, PBI , PLT , sIL 2R, and MgK levels were independent predictors of BMI. Conclusion PBI , PLT , sIL 2R, and MgK may be the useful laboratory markers for BMI diagnosis.