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Evaluation of the Sysmex XN‐550, a Novel Compact Haematology analyser from the XN‐L ® series, compared to the XN‐20 system
Author(s) -
Tailor H.,
Mackie I.,
Mellick A.,
Machin S.
Publication year - 2017
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12701
Subject(s) - analyser , hematology analyzer , nuclear medicine , white blood cell , medicine , mathematics , physics , optics , pathology , gastroenterology
The XN‐550 is a new, automated, compact, haematology analyser designed to generate a full blood count with a standard five‐part white blood cell differential and an immature granulocyte count, as well as an optional reticulocyte and optical platelet (PLT) counts. The aim of the study was to evaluate the performance of the XN‐550 and compare it to the established XN‐20 system. Methods We evaluated the basic parameter and special measurement channels of the XN‐550, using the XN‐20 (which has a similar operating system), as a reference analyser. Precision, carry‐over and throughput evaluations were performed. In addition, a total of 202 samples including normal controls and various pathological samples were studied for comparability. Results Good correlations with the reference analyser were obtained for all parameters except basophils. The XN‐550 offers impedance and optical PLT counts and the latter showed a better correlation and less scatter than the impedance count and was comparable to the XN‐20 fluorescent count at PLT counts ≤40×10 9 /L. Precision was good, and no significant carry‐over was detected. Conclusions The XN‐550 was simple and easy to use, while maintaining the good diagnostic sensitivity seen with high‐range systems such as the XN‐20, making this compact device suitable for near‐patient services and smaller satellite laboratories.