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The clinicopathologic significance of lymphocyte subsets in acute myeloid leukemia
Author(s) -
Alcasid M.,
Ma L.,
Gotlib J. R.,
Arber D. A.,
Ohgami R. S.
Publication year - 2017
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12594
Subject(s) - immune system , lymphocyte , immunology , myeloid leukemia , flow cytometry , myeloid , immunophenotyping , disease , leukemia , biology , medicine , pathology
Summary Introduction While the role of the immune system in altering and modulating the progression of solid tumors is well studied, the impact of the immune system on the outcome and progression of hematolymphoid neoplasms is still poorly understood. Methods Here, we report a retrospective study detailing our analysis of 130 patients with acute myeloid leukemia ( AML ), with flow cytometry immunophenotypic evaluation of major lymphocyte subsets including B cells, T cells, and NK cells. Results Our study identifies differential signatures of lymphocyte subsets pertaining to distinct subcategories of AML , and prognostic correlations in patients. In multivariate analysis, NK cells (specifically CD 56+/ CD 16+ NK cells at a cutoff of ≥5%) were found to be an independent indicator of improved overall and disease‐free survival; cytogenetic risk was also shown to be critical in stratifying patients with AML . Conclusions In total, we demonstrate that in AML , the subset distribution of immune system lymphocytes is nonrandom, and suggest an important role for distinct lymphocyte subsets, particularly NK cells, in this disease.