Premium
Spectrum of bone marrow morphologic findings in hepatitis C patients with and without prior liver transplantation
Author(s) -
Boone J. M.,
Cui W.
Publication year - 2016
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12559
Subject(s) - cytopenia , pancytopenia , medicine , gastroenterology , cirrhosis , liver transplantation , liver biopsy , bone marrow , hepatitis c , bone marrow examination , liver function tests , transplantation , pathology , myeloid , biopsy
Summary Introduction Cytopenia is a common hematologic finding in patients with HCV infection. Only a few studies have addressed bone marrow ( BM ) morphologic findings in these patients. No systemic study has been performed in these patients with liver transplantation ( LT ). Methods We retrospectively examined BM s in 49 hepatitis C patients with and without prior LT ( n = 19 and n = 30). Results Among the patients with an available complete blood count ( n = 46), the majority of them presented with cytopenia involving one or multiple cell lineages including unicytopenia (13%, n = 6), bicytopenia (31%, n = 14), and pancytopenia (43%, n = 20). Examination of the BM revealed a wide spectrum of morphologic findings ranging from benign reactive processes to overt malignant processes which included myeloid, lymphoid, and plasma cell neoplasms. The severity of cytopenia was not correlated with cirrhosis or antiviral therapy. However, the severity of cytopenia was partly correlated with splenomegaly or LT ( P < 0.05). Conclusions Cytopenia is a common finding in hepatitis C patients. Hypersplenism or LT has an adverse impact on some blood cell counts. Lastly, hepatitis C patients present with a wide spectrum of BM findings including malignant neoplasms, which indicates a diagnostic value of BM examination in these patients.