Laboratory testing for antiphospholipid syndrome | Zendy

Pengo V. | Zendy; Banzato A. | Zendy; Bison E. | Zendy; Denas G. | Zendy; Zoppellaro G. | Zendy; Bracco A. | Zendy; Padayattil Jose S. | Zendy; Hoxha A. | Zendy; Ruffatti A. | Zendy

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Laboratory testing for antiphospholipid syndrome

Author(s) -

Pengo V.,

Banzato A.,

Bison E.,

Denas G.,

Zoppellaro G.,

Bracco A.,

Padayattil Jose S.,

Hoxha A.,

Ruffatti A.

Publication year - 2016

Publication title -

international journal of laboratory hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.705

H-Index - 55

eISSN - 1751-553X

pISSN - 1751-5521

DOI - 10.1111/ijlh.12507

Subject(s) - lupus anticoagulant , antiphospholipid syndrome , medicine , anticardiolipin antibodies , diagnostic test , intensive care medicine , medical physics , immunology , antibody , pediatrics

Summary This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome ( APS ). After a general definition of APS , this study deals with appropriateness and timing in requesting the determination of antiphospholipid ( aPL ) antibodies. Lupus anticoagulant ( LAC ), anticardiolipin ( aCL ), and anti β2‐glycoprotein I (aβ GPI ) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians. Finally, a personal definition of APS according to aPL antibody profile closes the manuscript.

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