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Laboratory testing for antiphospholipid syndrome
Author(s) -
Pengo V.,
Banzato A.,
Bison E.,
Denas G.,
Zoppellaro G.,
Bracco A.,
Padayattil Jose S.,
Hoxha A.,
Ruffatti A.
Publication year - 2016
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12507
Subject(s) - lupus anticoagulant , antiphospholipid syndrome , medicine , anticardiolipin antibodies , diagnostic test , intensive care medicine , medical physics , immunology , antibody , pediatrics
Summary This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome ( APS ). After a general definition of APS , this study deals with appropriateness and timing in requesting the determination of antiphospholipid ( aPL ) antibodies. Lupus anticoagulant ( LAC ), anticardiolipin ( aCL ), and anti β2‐glycoprotein I (aβ GPI ) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians. Finally, a personal definition of APS according to aPL antibody profile closes the manuscript.