Premium
Evaluation of parameters obtained from the Sysmex XN‐2000 for predicting the recovery of the absolute neutrophil count and platelets after hematopoietic stem cell transplantation
Author(s) -
Park S.H.,
Park C.J.,
Kim M.J.,
Han M.Y.,
Lee B.R.,
Cho Y.U.,
Jang S.,
Kwon S.W.,
Kim D.Y.,
Lee J.H.,
Lee J.H.,
Lee K.H.
Publication year - 2016
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12470
Subject(s) - platelet , mean platelet volume , hematopoietic stem cell transplantation , medicine , transplantation , haematopoiesis , absolute neutrophil count , stem cell , immunology , gastroenterology , biology , neutropenia , toxicity , genetics
Summary Introduction We analyzed abilities of parameters from Sysmex XN ‐2000 (Sysmex, Kobe, Japan) to predict absolute neutrophil count ( ANC ) and platelet recovery after hematopoietic stem cell transplantation ( HSCT ) in patients with hematologic malignancies. Methods We prospectively analyzed 911 follow‐up peripheral blood samples from 44 HSCT ‐performed patients and evaluated the performances of the following parameters: WBC , immature granulocyte ( IG ), hematopoietic stem and progenitor cells ( HPC ), immature reticulocyte fraction ( IRF ), immature platelet fraction ( IPF ), platelet distribution width ( PDW ), mean platelet volume ( MPV ), and platelet larger cell ratio (P‐ LCR ). Results When compared to four other parameters, the identification of initiation in IG (%)/ HPC (%) increase enabled earlier prediction of ANC recovery to >500/ μ L and >1000/ μ L with more time benefit of 3.5–6.5 days/2.0–5.0 days and 3.0–6.0 days/2.0–5.0 days, respectively. When compared to IPF (%), the identification of initiation in PDW , MPV , and P‐ LCR (%) increase enabled earlier prediction of platelet recovery to >20 000/ μ L and >50 000/ μ L with more time benefit of 2.5–3.5 days and 2.0–3.0 days, respectively. However, the standard deviation of time benefit obtained from IG (%)/ HPC (%)/ PDW / MPV /P‐ LCR (%) was consistently large (3.0–4.3 days). Conclusions There is a systematic pattern where a rise in most of the studied parameters can be observed in most patients before ANC /platelet recovery. However, the interindividual variation between the time of rise of these parameters and ANC /platelet recovery is large, and therefore, using these parameters to predict recovery in the individual patient is probably not meaningful in the clinical setting.