Premium
Thrombocytopenia: an update
Author(s) -
Smock K. J.,
Perkins S. L.
Publication year - 2014
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12214
Subject(s) - medicine , etiology , intensive care medicine , bone marrow , work up , peripheral blood , platelet , bone marrow aspirate , bone marrow failure , pathology , surgery , stem cell , haematopoiesis , biology , genetics
Summary Thrombocytopenia is a common clinical problem with numerous potential causes including decreased bone marrow platelet production, increased peripheral platelet destruction, increased splenic sequestration, and dilution. Investigation of the etiology of thrombocytopenia requires careful consideration of clinical history and laboratory features. A complete blood count and peripheral smear review are essential components of the diagnostic work‐up, and physicians should be knowledgeable about appropriate selection and interpretation of more specialized tests, including bone marrow examination, to assist with diagnosis. This review article aims to summarize and address appropriate work‐up of the major and/or life‐threatening causes of thrombocytopenia and some of the better‐characterized congenital thrombocytopenias.