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Variations of hairy cell nuclei shapes with regard to ring‐shaped nuclei simulating dysplastic neutrophilic granulocytes and review of the literature
Author(s) -
Lemež P.,
Kačírková P.
Publication year - 2014
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/ijlh.12195
Subject(s) - nucleus , bone marrow , cytology , pathology , medicine , chemistry , nuclear medicine , psychiatry
Summary Introduction Nuclei of hairy cells ( HC ) are typically oval, round or indented, but atypical shapes are occasionally described in HCL and may lead to a provisional wrong diagnosis. Methods The aim of this study was to quantify HC nuclei shapes classified into 11 categories on diagnostic bone marrow smears of 38 consecutive patients with HCL . Results HC in all 33 patients with evaluable smears at diagnosis exhibited a round/oval nucleus in 60.8–95.8%, an indented nucleus in 3.4–24.5% and a kidney‐shaped nucleus in 0.4–7.0%. Other shapes of HC nuclei were found only in a proportion of patients: nuclei with two indentations in 0.4–6.5% HC (28 patients), overlapped nuclei in 0.5–3.5% HC (17) and lobulated nuclei in 0.4–4.5% HC (15). Two per cent or less of HC had the following nuclear shapes: that of an opposite indentation and impression (14 patients), dumb‐bell (13), ring (10), horseshoe (5), two nuclei (8 patients). Conclusion Different shapes of HC nuclei similar to cells typical for other diagnoses are found usually in low frequencies. However, if their numbers are increased, they may cause diagnostic problems because cytology of blood and bone marrow smears is usually the first available diagnostic method.