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Association between the interferon‐ γ +874 T/A polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta‐analysis
Author(s) -
Lee Young Ho,
Song Gwan Gyu
Publication year - 2022
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12599
Subject(s) - odds ratio , genotype , medicine , rheumatoid arthritis , immunology , allele , meta analysis , confidence interval , polymorphism (computer science) , gastroenterology , biology , genetics , gene
We aimed to determine whether the interferon (IFN) ‐γ +874 T/A polymorphism (rs2430561) is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta‐analysis was conducted to assess the association between the IFN ‐γ +874 T/A polymorphism and SLE or RA using allele contrast, homozygous contrast, recessive, and dominant models. A total of nine studies (six on SLE and three on RA), involving 1839 patients and 2272 controls, were included in the meta‐analysis. The meta‐analysis revealed a significant association between SLE and the TT genotype of the IFN ‐γ +874 T/A polymorphism (odds ratio [OR] = 0.751, 95% confidence interval [CI] = 0.634–0.899, p = .001), and stratification by ethnicity indicated an association between the IFN ‐γ +874 TT genotype and the Asian population. The analysis also revealed a significant association between SLE and the TT + TA genotype of the IFN ‐γ +874 T/A polymorphism in Arab populations (OR = 1.598, 95% CI = 1.053–2.425, p = .028). However, no association between the IFN ‐γ +874 T/A polymorphism and RA was found using allele contrast, recessive, dominant or homozygous contrast models in all study subjects and ethnic groups. This meta‐analysis demonstrated that the IFN ‐γ +874 T/A polymorphism is associated with susceptibility to SLE in Asian and Arab populations.