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Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis
Author(s) -
Andrade Fabiana,
Eibofner Isabela,
Pieczarka Cristhine,
van Tong Hoang,
Sena Leia,
Skare Thelma,
Utiyama Shirley,
MessiasReason Iara,
Velavan Thirumalaisamy
Publication year - 2021
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12533
Subject(s) - gene , allele , rheumatoid arthritis , complement system , biology , immune system , complement component 2 , genetics , immunology , complement receptor
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.