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HLA‐G: Function, polymorphisms and pathology
Author(s) -
ArnaizVillena Antonio,
Juarez Ignacio,
SuarezTrujillo Fabio,
LópezNares Adrián,
Vaquero Christian,
PalacioGruber Jose,
MartinVilla Jose M.
Publication year - 2021
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12513
Subject(s) - human leukocyte antigen , disease , hla g , function (biology) , biology , immunology , medicine , genetics , pathology , antigen
HLA‐G immune modulatory genes and molecules are presently being studied by a widespread number of research groups. In the present study, we do not aim to be exhaustive since the number of manuscripts published every year is overwhelming. Instead, our aim is pointing out facts about HLA‐G function, polymorphism and pathology that have been confirmed by several different researchers, together with exposing aspects that may have been overlooked or not sufficiently remarked in this productive field of study. On the other hand, we question whether performing mainly studies on HLA‐G and disease associations is going to give a clear answer in the future, since 40 years of study of classical HLA molecules association with disease has still given no definite answer on this issue.