HLA‐B*15:47:01 allele with undefined serological equivalent considered as B Blank | Zendy

Desoutter Judith | Zendy; Jacob Valentine | Zendy; Guillaume Nicolas | Zendy

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HLA‐B*15:47:01 allele with undefined serological equivalent considered as B Blank

Author(s) -

Desoutter Judith,

Jacob Valentine,

Guillaume Nicolas

Publication year - 2020

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12457

Subject(s) - serology , allele , human leukocyte antigen , typing , immunology , antigen , hla b , serotype , biology , histocompatibility testing , epitope , antibody , genetics , gene

We report a discordance between complement‐dependent cytotoxicity and next‐generation sequencing molecular typing revealing HLA‐B*15:47:01 allele with undefined serological equivalent confirmed by high‐level immunization against the B15 serotype. Due to the high‐level immunization against HLA‐B15 and B70 antigens, we considered the HLA‐B*15:47:01 allele to be B Blank and not as B15 or B70 serological specificity.

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