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HLA‐B*15:47:01 allele with undefined serological equivalent considered as B Blank
Author(s) -
Desoutter Judith,
Jacob Valentine,
Guillaume Nicolas
Publication year - 2020
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12457
Subject(s) - serology , allele , human leukocyte antigen , typing , immunology , antigen , hla b , serotype , biology , histocompatibility testing , epitope , antibody , genetics , gene
Abstract We report a discordance between complement‐dependent cytotoxicity and next‐generation sequencing molecular typing revealing HLA‐B*15:47:01 allele with undefined serological equivalent confirmed by high‐level immunization against the B15 serotype. Due to the high‐level immunization against HLA‐B15 and B70 antigens, we considered the HLA‐B*15:47:01 allele to be B Blank and not as B15 or B70 serological specificity.