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The HLA‐DRB1 risk alleles for multiple sclerosis are differentially expressed in blood cells of patients from Southern Italy
Author(s) -
Pisapia Laura,
Cerillo Ilaria,
Farina Federica,
Zimbardo Arianna,
Barba Pasquale,
Orefice Giuseppe,
Gianfrani Carmen,
Strazzullo Maria,
Del Pozzo Giovanna
Publication year - 2019
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12450
Subject(s) - allele , multiple sclerosis , human leukocyte antigen , cohort , gene , biology , autoimmune disease , genetics , immunology , medicine , antigen , antibody
HLA gene expression has an important role in the autoimmune disease predisposition. We investigated the mRNA expression profile of the risk alleles HLA‐DRB1*15 and HLA‐DRB1*13 in a cohort of subjects both multiple sclerosis (MS) patients and healthy controls. Moreover, we explored the expression of the allele HLA‐DRB1*11 that is very frequent in our cohort from southern Italy. We found that the expression of MS‐associated alleles in heterozygous MS patients was always higher than the nonassociated alleles. The differential risk allele expression occurred also in nonaffected subjects, though with a lower increment compared to MS patients.