Premium
Association between human leucocyte antigen alleles and risk of stroke in Iranian population
Author(s) -
Sayad Arezou,
Akbari Mohammad Taghi,
Inoko Hidetoshi,
Khazaei Mojtaba,
Mehdizadeh Bijan,
Taheri Mohammad,
GhafouriFard Soudeh
Publication year - 2019
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12421
Subject(s) - allele , human leukocyte antigen , stroke (engine) , genotype , haplotype , medicine , population , case control study , immunology , antigen , biology , genetics , gene , mechanical engineering , environmental health , engineering
Previous studies have demonstrated associations between human leucocyte antigen (HLA) and some types of ischaemic stroke. In the present study, we genotyped HLA‐A,‐B and ‐DRB1 alleles in 140 Iranian patients with history of ischaemic stroke and 140 age‐/sex‐matched healthy subjects. No significant difference has been found in the distribution of HLA‐A and B alleles between cases and controls. The DRB1*16 allele was significantly over‐represented in patient group compared with control group (Adjusted p value = 0.048). Other HLA‐DRB1 alleles were not associated with stroke risk. The HLA‐B*35,B*52 genotype was significantly more prevalent among patients compared with controls (Adjusted p value = 0.03, OR [95% CI] = 9.3 [1.3, 407.2]). Several HLA haplotypes were associated with risk of stroke in the assessed population. The current study provides further evidences for participation of HLA in conferring risk of ischaemic stroke.