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Characterization of a novel MICB variant in an individual from the Chinese Uyghur population, MICB*005:09 , by cloning and sequencing
Author(s) -
Tursun Mikrban,
Wang ZhenFang,
Guo WenTao,
Hasim Ayshamgul,
Tian Wei
Publication year - 2019
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12410
Subject(s) - sanger sequencing , biology , genetics , cloning (programming) , exon , allele , dna sequencing , gene , microbiology and biotechnology , computer science , programming language
Summary A new allelic variant in MICB*005 lineage, MICB*005:09 , has been identified in a male Uyghur individual recruited from Xinjiang Uyghur Autonomous Region, China by PCR‐sequence‐based typing (Sanger sequencing) and confirmed by cloning and sequencing. Aligned with MICB*005:03 , this new allelic variant shows a synonymous T substitution at nucleotide position 8 in exon 2, corresponding to codon 3 (CAC→CAT) of the mature MICB mRNA transcript.