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Genomic sequences of HLA ‐A*68:169, HLA ‐B*07:298 and HLA ‐B*39:129.
Author(s) -
Balas A.,
Planelles D.,
RodríguezCebriá M.,
Puig N.,
Vicario J. L.
Publication year - 2018
Publication title -
international journal of immunogenetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.41
H-Index - 47
eISSN - 1744-313X
pISSN - 1744-3121
DOI - 10.1111/iji.12360
Subject(s) - hla b , human leukocyte antigen , exon , genetics , gene , microbiology and biotechnology , biology , allele , amino acid , signal peptide , antigen , peptide sequence
Summary Three new HLA class I alleles were described in the Spanish population. HLA ‐A*68:169 and ‐B*39:129 show one amino acid replacement at the α1‐domain, compared to A*68:02 (P47 > L47) and ‐B*39:06 (S11 > A11), respectively. HLA ‐B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position −14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA ‐B genes.