Characterization of a novel   HLA ‐B*39:01:01‐ related allele,   HLA ‐B*39:130 , by cloning and phasing | Zendy

Li L. X. | Zendy; Tian W. | Zendy; Zhu F. M. | Zendy; Wang W. Y. | Zendy; Cai J. H. | Zendy

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Characterization of a novel HLA ‐B*39:01:01‐ related allele, HLA ‐B*39:130 , by cloning and phasing

Author(s) -

Li L. X.,

Tian W.,

Zhu F. M.,

Wang W. Y.,

Cai J. H.

Publication year - 2017

Publication title -

international journal of immunogenetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.41

H-Index - 47

eISSN - 1744-313X

pISSN - 1744-3121

DOI - 10.1111/iji.12345

Subject(s) - nonsynonymous substitution , microbiology and biotechnology , biology , genetics , exon , sanger sequencing , human leukocyte antigen , cloning (programming) , allele , epitope , gene , dna sequencing , antigen , genome , computer science , programming language

Summary A novel HLA ‐B*39:01:01 ‐related variant, HLA ‐B*39:130 , has been identified in a normal individual of Han ethnicity in Hunan province, southern China. Following Sanger polymerase chain reaction–sequence‐based typing ( PCR ‐ SBT ), this new allele was further confirmed by cloning, phasing and sequencing. Aligned with HLA ‐B*39:01:01 , HLA ‐B*39:130 has a nonsynonymous thymine substitution at nucleotide position 94 in exon 4, resulting in amino acid change from threonine to isoleucine at codon 214 ( ACA → ATA ) of the mature HLA ‐B mRNA molecule.

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